WAKEFIELD DARREN H,ROSSI NICHOLAS,ROZEMA DAVID B,ALMEIDA LAUREN,PERILLA NICHOLAS Anthony L
申请号：
IN52/MUMNP/2014
公开号：
IN2014MN00052A
申请日:
2014.01.13
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
