ANTAGONISTS FOR INTERLEUKIN-17 RECEPTOR B (IL-17RB) AND ITS LIGAND IL-17B FOR CANCER THERAPY

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专利权人:

Wen-Hwa Lee;Academia Sinica

发明人:

Wen-Hwa Lee,Jin-Yuh Shew,Che Ma,Chia-Lin Chen,Wen-Hsin Lee,Chun-Kai Huang,Heng-Hsiung Wu

申请号：

US15322788

公开号：

US20180201672A1

申请日:

2015.06.30

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.

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