PROBLEM TO BE SOLVED: To provide a preparation capable of specifically delivering an Rho kinase inhibitor to a liver stellate cell to treat hepatic ischemia and reperfusion injury.SOLUTION: A vitamin A added liposome preparation contains an Rho kinase inhibitor, and is mixed at the molar ratio of the Rho kinase inhibitor to vitamin A of 1:3 to 1:5, and at the molar ratio of the total lipid in the constituent lipid to vitamin A of 1:0.03 to 1:0.3. The present invention also provides a production method thereof.COPYRIGHT: (C)2014,JPO&INPIT【課題】肝虚血再再灌流障害を処置するための、Rhoキナーゼ阻害剤を肝星細胞に特異的に送達できる製剤の提供。【解決手段】Rhoキナーゼ阻害剤を含み、Rhoキナーゼ阻害剤とビタミンAの比率がモル比で1:3~1:5であり、構成脂質の総脂質量とビタミンAとをモル比で1:0.03~1:0.3の比率で混合したビタミンA付加リポソーム製剤およびその製造方法。【選択図】なし
