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use of dihydromyretin for the preparation of a drug to be administered to gabaa receptors that will be, are and / or have been exposed to ethanol; exposure to ethanol.
专利权人:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
IGOR SPIGELMAN,JING LIANG,RICHARD W. OLSEN
申请号:
BR112013003946
公开号:
BR112013003946A2
申请日:
2011.08.23
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
Disclosed herein are methods for treating alcohol intoxication, alcohol use disorders and alcohol abuse which comprise the administration of dihydromyricetin. As disclosed herein, dihydromyricetin potentiates the activity of GABAARs having the alpha4-beta-delta subunit which is associated with the effects of ethanol, antagonizes the actions of ethanol on the GABAARs, acts on the benzodiazepine sites of GABAARs, and inhibits, reduces and/or reverses some or all of the GABAAR plasticity which is caused by exposure to ethanol.
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