An air-way tube holder (100) includes a face plate (102) having a v-shaped tube-receiving surface (114) that aligns with one side of an opening through the face plate, and a holding block (112), which is disposed near a second side of the opening. The holding block receives a thumb screw (130) and an engagement arm (142), the latter including a clamping head (144), which directly opposes the tube-receiving surface. The thumb screw is adapted to move the clamping head toward the tube-receiving surface to immobilize an airway tube therebetween, either by sliding the thumb screw (gross adjustment) or turning the thumb screw (fine adjustment). The thumb screw/clamping head is releasable by actuating a quick-release mechanism (694).