A catheter securement device holds a medical article such as a catheter in position upon the body of a patient and at least inhibits longitudinal movement of the medical article. The securement device includes a retainer and a clamp. The retainer and clamp can include interengaging structure that can include a ratchet mechanism that allows a single securement system to be used with medical articles that have different longitudinal lengths as well as medical articles that have distally located contact surfaces.