CIAPETTI, PAOLA,CHERY-MOZZICONACCI, FLORENCE,WERMUTH, CAMILLE, G
申请号：
NZ58759009
公开号：
NZ587590A
申请日:
2009.02.26
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
The subject of the invention is 7-substituted 3-carboxy-oxadiazino-quinoline derivatives of formula(I) in which: either R1 represents: H, OH, NH2 , -(CH2)m - NRaRb in which m = 0, 1 or 2, Ra and Rb are identical or different and represent H, linear, branched or cyclic (C1-C6) alkyl, (C3-C6) cycloalkyl-(C1-C6)-alkyl or also represent Rc, S(O)2Rc, C(O)Rc, S(O)2Rd or C(O)Rd or Ra and Rb form together with the nitrogen atom, an Rc radical Rc represents a saturated, unsaturated or aromatic 5- to 6-member ring containing 1 to 4 heteroatoms chosen from N, O and S, optionally substituted by 1 to 3 (C1-C6) alkyl radicals, said ring being linked, if appropriate, to the nitrogen atom of NRaRb by a nitrogen atom or a carbon atom Rd represents a linear or branched (C1-C6) alkyl or (C3-C6) cyclic alkyl radical, optionally substituted by 1 to 4 halogens or R1 represents Rc or CHReRc or CHReRd Rc and Rd are as defined above, Re represents H, OH, NH2, NH-(C1-C6)-alk or N-(C1-C6)-alk2, or NH-(C1-C7)-acyl or NHRc, Rc being as defined above R2 represents: H, (CH2)m-NRaRb, Rc, CHReRc or CHReRd, Ra, Rb, Rc, Rd and Re are as defined above and R2 represents H it being understood that R1 and R2 cannot at the same time be H or that R1 and R2 or R2 and R1 cannot be one (CH2)m-NRaRb or Rc or H and the other one OH, or one H and the other one Rc or NH2, or one H and the other one (CH2)m-NRaRb in which Ra and Rb represent H or (C1-C6) alkyl or C(O)Rd, in which Rd represents an unsubstituted linear or branched (C1-C6) alkyl or (C3-C6) cyclic alkyl radical - or R1 has the above definition except H and R2 and R2 together represent gem (C1-C6) dialkyl or (C1-C6) alkyl-oxime, or R2 and R2 represent respectively Rc or Rd and OH, NH2, NHRc or NHRf, Rc and Rd being as defined above and Rf being a (C1- C7) acyl radical - or R1 represents H and R2 and R2 together represent (C1-C6) alkyl-oxime or one represents Rc and the other one represents OH, NH2, NHRc or NHRf, Rc and Rf being defined as above n is 0 o
