Compounds derived from 2-amino-5 - (trifluoromethyl) - furo [3,4-d] thiazine, as inhibitors of the production of beta Amyloid Protein； Pharmaceutical Composition and its use for treating or Preventing a neurodegenerative disease such as Alzheimer type Dementia and senile dementia, and to Treat or prevent Get Type 2 diabetes.
HALL, ADRIAN,FARTHING, CRISTOPHER NEIL,CASTRO, PINERO, JOSE, LUIS
申请号：
CL2013002083
公开号：
CL2013002083A1
申请日:
2013.07.19
申请国别(地区):
CL
年份:
2013
代理人:
摘要：
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine； A is CH or N； Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or &mdash；C&equiv；N； and pharmaceutically acceptable salts thereof； which compound has an A&bgr； production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by A&bgr； and typified by Alzheimer-type dementia.COMPUESTOS DERIVADOS DE 2-AMINO-5-(TRIFLUOROMETIL)-FURO[3,4-D]TIAZINA, COMO INHIBIDORES DE LA PRODUCCION DE LA PROTEINA BETA-AMILOIDE； O INHIBIDOR DE BACE； COMPOSICION FARMACEUTICA ； Y SUS USO PARA TRATAR O PREVENR UNA ENFERMEDAD NEURODEGENERATIVA TAL COMO LA DEMENCIA TIPOP ALZHEIMER, Y PARA TRATAR O PREVENIR LA DIABBETES TIPO 2.
