Jordan Marshall Sand,Mark Eric Cook,Daniel Elmer Butz
申请号：
US13667346
公开号：
US20140127190A1
申请日:
2012.11.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Described herein are peptides from secretory phospholipase A2-IB and antibodies that can be used to reduce the contribution of the gastrointestinal tract to inflammatory processes including systemic inflammatory responses. Specifically, antibodies that bind specifically a peptide from secretory phospholipase A2-IB prevent death in a mouse model of LPS-induced endotoxemia. The antibodies described herein are particularly useful to treat systemic inflammatory response syndromes, including sepsis.
