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Method for the preparation of a crystalline form of 1-chloro-4- (beta-d-glucopyranos-1-yl)-2-(4-((s)-tetrahydrofuran-3-yloxy)benzyl)benzene
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
WEBER DIRK,RENNER SVENJA,FIEDLER TOBIAS,ORLICH SIMONE
申请号:
NZ59831810
公开号:
NZ598318A
申请日:
2010.09.24
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
IP No. 598318 The disclosure relates to a method for the preparation for a crystalline form of 1-chloro-4-(&Bgr;- D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene. The method of the disclosure comprises precipitating the compound from a mixture of two solvents, toluene/ethanol, toluene/1-propanol, toluene/2-propanol, tetrahydrofuran/ethanol, tetrahydrofuran/1-propanol and tetrahydrofuran/2-propanol being preferred. In addition the invention relates to a crystalline form obtainable by this method, to a pharmaceutical composition and to the use thereof for preparing medicaments. Conditions that may be treated with the medicaments of the disclosure include: type 1 and type 2 diabetes mellitus, complications of diabetes, metabolic acidosis or ketosis, reactive hypoglycaemia, hyperinsulinaemia, glucose metabolic disorder, insulin resistance, metabolic syndrome, dyslipidaemias of different origins, atherosclerosis and related diseases, obesity, high blood pressure, chronic heart failure, oedema and hyperuricaemia.
来源网站:
中国工程科技知识中心
来源网址:
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