Scott, Jack D.,Stamford, Andrew W.,Gilbert, Eric J.,Cumming, Jared N.,Iserloh, Ulrich
申请号：
AU2013234424
公开号：
AU2013234424B2
申请日:
2013.09.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2013234424B220140227.pdf#####IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE Abstract In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereo isomers thereof, and pharmaceutically acceptable salts of said compounds stereo isomers, wherein each of R', R2, R3, R4, R', R9, ring A, ring B, m, n, p, -L1-,L2-, and L3is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to B-amyloid (AB) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (AB) protein, including Alzheimers disease, are also disclosed.
