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Melatonin formulations and methods for preparation and use.
专利权人:
VERSAILLES B.V.
发明人:
AN DE NAEYER,JOHANNES DIRK VAN DEN BERG
申请号:
NL2015272
公开号:
NL2015272A
申请日:
2015.08.05
申请国别(地区):
NL
年份:
2017
代理人:
摘要:
The current invention is directed to a method for the manufacturing of a solid formulation comprising melatonin as active pharmaceutical ingredient, said method comprises a melatonin dispersion step in one or more intragranular excipients to form a melatonin blend, followed by a wet granulation step. In a second aspect, the invention describes a tablet comprising melatonin, whereby said tablet is an immediate release formulation and whereby said tablet comprises: - between 0.5 and 10% w/w of melatonin; - between 75 and 99% w/w of one or more fillers; - between 0.5 and 5% w/w of one or more binders; - between 0.05 and 0.5% of one or more glidants; and - between 0.25 and 1% w/w of one or more lubricants.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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