The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts of resorcinol derivatives as Hsp90 inhibitors. The compound of the invention has the activity of inhibiting heat shock protein Hsp90. The compounds of the present invention are thus used for the treatment of proliferative diseases and neurodegenerative diseases such as cancer. The invention also provides methods for preparing these compounds and pharmaceutical compositions containing them, methods for treating diseases, and pharmaceutical compositions containing these compounds.本發明涉及作爲HSP90抑制劑的間苯二酚類衍生物的式(I)化合物或其藥學上可接受的鹽。本發明的化合物具有抑制熱休克蛋白HSP90的活性。本發明的化合物因此用於治療例如癌症的增殖疾病和神經變性疾病。本發明也提供了這些化合物和包含它們的藥物組合物的製備方法,治療疾病的方法和包含這些化合物的藥物組合物。