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NOVEL IMMUNOTHERAPEUTIC TREATMENTS FOR TUMOURS
专利权人:
Bergen Teknologioverføring AS
发明人:
Bjørn Tore Gjertsen,Karl-Henning Kallang,Anne Margrete Øyan
申请号:
US16345623
公开号:
US20190269726A1
申请日:
2017.10.27
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention provides a method for the treatment of a tumour in a subject, said method comprising administering (i) an autologous immature dendritic cell, or a precursor thereof, and (ii) an immune cell checkpoint inhibitor to said subject subsequent to the at least partial ablation of said tumour in said subject, wherein the administration of said autologous immature dendritic cells, or a precursor thereof, and said immune cell checkpoint inhibitor is local to the site of the ablated tumour or part thereof. The invention further provides a product containing an autologous immature dendritic cell, or a precursor thereof, and an immune cell checkpoint inhibitor as a combined preparation for separate, simultaneous or sequential use in a method for the treatment of a tumour in a subject, said method comprising administering (i) the autologous immature dendritic cell, or a precursor thereof, and (ii) the immune cell checkpoint inhibitor to said subject subsequent to the at least partial ablation of said tumour in said subject, wherein the administration of said autologous immature dendritic cells, or a precursor thereof, and said immune cell checkpoint inhibitor is local to the site of the ablated tumour or part thereof.
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