The invention relates to an aqueous pharmaceutical formulation with an insulin, insulin analog or insulin derivative, and methionine; and also to its preparation, use for treating diabetes mellitus, and to a medicament for treating diabetes mellitus.本發明係關於一種含胰島素、胰島素類似物或胰島素衍生物和甲硫胺酸的水性醫藥調配物;以及亦係關於其用於治療糖尿病的製劑,和一種用於治療糖尿病的藥物。