ANTICORPS PRÉSENTANT UNE ACTIVITÉ ACCRUE ET SON PROCÉDÉ DE MODIFICATION

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

申请号：

EP16878867.7

公开号：

EP3395835A1

申请日:

2016.12.22

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

As a result of producing ACE910 variants in which various sites of the constant regions were modified, the inventors discovered bispecific antibodies having FVIII mimetic activity higher than that of ACE910. The inventors also identified mutation positions that elevate the FVIII mimetic activity and discovered methods for elevating the FVIII mimetic activity by using the mutations.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/