< Topic >Offer of the chemical compound which is beneficial to the remedy of disease and the disease which are mediated inhibition or the adjustment of activity of the HIV integuraze enzyme, especially, by inhibition and HIV infection, AIDS and HIV of HIV duplication.SolutionsAmong X those, as for Y, R - R it is defined in the bill as for this invention, the chemical compound which is displayed with formula (i), or in regard to the salt, the solvent dishes dressed with sauce, or the constituent which that pharmacy are allowed. The chemical compound which is displayed with formula (i) inhibits the HIV integuraze enzyme, is pulled up HIV infection, by AIDS or AIDS-related syndrome (ARC), and HIV infection or or it is beneficial to other diseases and the prevention and the remedy which of the disease are mediated.【課題】HIVインテグラーゼ酵素の活動の阻害または調節、特に、HIV複製の阻害及びHIV感染、AIDS、HIVにより媒介される疾病及び疾患の治療に有益な化合物の提供。【解決手段】本発明は、式(I)で表される化合物、またはその薬学的に許容される塩、溶媒和物、もしくは組成物に関し、そのうちX、Y、R1~R5は明細書において定義される。式(I)で表される化合物はHIVインテグラーゼ酵素を阻害し、HIV感染、AIDSまたはエイズ関連症候群(ARC)、及びHIV感染により引き起こされるかまたは媒介されるその他の疾病および疾患の予防と治療に有益である。
