In an alternative embodiment, the invention provides compositions, e.g., formulations or preparations, which are used to treat, ameliorate or prevent other disorders associated with constipation and gastrointestinal symptoms. to provide. In an alternative embodiment, the present invention provides a method of treating a condition selected from the group consisting of cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue syndrome (CFS) ), Intestinal bloating, proctalgia fugax, small intestinal bacterial overgrowth (SIBO) and large intestinal bacterial overgrowth (LIBO), chronic nausea, functional Such as a formulation or preparation, which is used to treat, ameliorate or prevent symptoms that benefit from increased or slowed bowel movement, including functional dyspepsia and bloating. In an alternative embodiment, the invention provides a method of treating constipation, functional constipation, Irritable Bowel Syndrome (IBS) -constipation, pseudo-obstruction, slow-transit constipation, For example, a formulation or manufacture, which is used to treat, ameliorate or prevent diabetes mellitus, stasis with overflow and / or diabetic gastro-paresis. In an alternative embodiment, the invention provides pharmaceuticals and products (articles) of manufacture to carry the composition and formulation to an individual, e.g., a human or animal.대안적 실시형태에서, 본 발명은 변비(constipation) 및 위장관 증상(gastrointestinal symptoms)과 관련된 다른 장애를 치료, 개선 또는 예방하는데 사용되는, 조성물, 예를 들면, 제제(formulations) 또는 제조(preparations)를 제공한다. 대안적 실시형태에서, 본 발명은 주기성 구토(cyclic vomiting), 역류성 식도염(reflux oesophagitis), 자폐증 장질환(autism enteropathy), 고창(flatulence), 구취(halitosis), 만성피로(Chronic's Fatigue Syndrome(CFS)), 각통질(bloating), 직장신경통(proctalgia fugax), 소장세균과다증식증(small intestinal bacterial overgrowth(SIBO)) 및 대장세균과다증식증(large intestinal bacterial overgrowth(LIBO)), 만성구역질(chronic nausea), 기능성 소화불량(functional dyspepsia) 및 각통질(bloating)을 포함하는, 창자 이동 증가 또는 속도로부터 혜택을 받는 증상을 치료, 개선 또는