Process and pharmaceutical for preparing (4S) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide Its purification for use as an active ingredient
The present invention relates to (4S) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3- of formula (I) It relates to a new and improved process for the preparation of carboxamides and also relates to (4S) -4- (4-cyano-2-methoxyphenyl) -5-ethoxy-2,8-dimethyl-1, of formula (I) It also relates to the preparation and use of crystalline polymorph I of 4-dihydro-1,6-naphthyridine-3-carboxamide.本発明は、式（I） の（4S）－4－（4－シアノ－2－メトキシフェニル）－5－エトキシ－2，8－ジメチル－1，4－ジヒドロ－1，6－ナフチリジン－3－カルボキサミドを調製するための新規かつ改善されたプロセスに関し、また、式（I）の（4S）－4－（4－シアノ－2－メトキシフェニル）－5－エトキシ－2，8－ジメチル－1，4－ジヒドロ－1，6－ナフチリジン－3－カルボキサミドの結晶多形Iの調製および使用にも関する。
