JUNG, SUNG YOUB,CHOI, IN YOUNG,KIM, MIN YOUNG,CHOI, JAEHYUK
申请号：
ARP180102806
公开号：
AR113258A1
申请日:
2018.09.28
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
1. This report deals with dipeptide derivatives similar to glucose (GLP-2)；Its modification and usage Currently, it also involves the production of dipeptide derivatives similar to glucose (GLP-2) and one of the compositions. Requirement 1: a glucose-2 (GLP-2) peptide copolymer,A GLP-2 derivative is covalently bound to an FC immunoglobulin, and a non cucumber polymer is used at both ends of the non cucumber polymer terminal, where the non cucumber polymer is selected from the polyethylene glycol and polypropylene glycol groups, Poly (vinyl chloride) - propylene glycol, poly (acyl polyoxyethyl ester), polyvinyl alcohol, polyurethane, glucose, polyethylene ether, aliphatic polymer, kitina, hyaluronic acid, and combinations of these substances. Claim 2: GLP-2 relocation in accordance with claim 1,GLP-2 derivatives contain a series of amino acids. The general formula is as follows (1): x1 xx2-dgsssdndelaldnwlqtx3 ° 83044； itdx3 83088 (SEQ ID No.9) (1),X1 in the former formula is: hididina, imidazoacetyl dehistidina, demaminohididina, b-hydroxidazoproprionideshidina, n-dimethydidina. O b-carboxii midazopropionildeshidina； X2 is alanina, glizina, or 2-aminosobutiric (AIB)；X3 ° 83044 is lysine or argon； x3 ° 83088 is deficient, or lysine, arginina, glutamine, histidina, 6-azido-lysine or crocin； provided, however, that any sequence identical to one sequence of an amino acid shall not be included in SEQ ID 1 of general formula (1).La presente se refiere a derivados del péptido 2 similar al glucagón (GLP-2), sus conjugados y su uso. La presente también se refiere a un método para producir un derivado del péptido 2 similar al glucagón (GLP-2) y un conjugado del mismo. Reivindicación 1: Un conjugado de péptido tipo glucagón 2 (GLP-2), en el que un derivado de GLP-2 y una región Fc de inmunoglobulina están cada uno unidos de modo covalente por medio de un polímero no peptidilo en ambos extremos terminales del polímero no peptidilo, en el que el polímero no peptidilo se seleccio
