Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.本發明提供通過計量供應劑量吸入器經由肺部或鼻遞送二或更多種活性藥劑的組成物、方法與系統。在一個具體例中，組成物包括懸浮介質、活性藥劑粒子及懸浮粒子，其中活性藥劑粒子及懸浮粒子在懸浮介質內形成共懸浮液。
