Advaxis, Inc.; Inc.;Augusta University Research Institute, Inc.;Advaxis
发明人:
KHLEIF, Samir,MKRTICHYAN, Mikayel,PETIT, Robert,WALLECHA, Anu
申请号：
EP15871241
公开号：
EP3234106A4
申请日:
2015.12.18
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Disclosed herein are compositions comprising use of compositions comprising a live attenuated recombinant Listeria strain comprising a fusion protein of a truncated listeriolysin O (LLO) protein, a truncated ActA protein, or a PEST amino acid sequence fused to a heterologous antigen, including a tumor-associated antigen, wherein the compositions further comprise or are co-administered with an antibody or fragment thereof. Also disclosed are combination therapies comprising use of these compositions comprising live attenuated recombinant Listeria strains, in conjunction with an antibody or fragment thereof for use in treating, protecting against, and/or inducing an immune response against a tumor, especially wherein the treating, protection against and/or inducing an immune response increases percent survival in a subject.
