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TRAITEMENT D'UNE MALADIE CARDIOVASCULAIRE A L'AIDE DE PIEGES DE LIGANDS D'ACTRII
专利权人:
CELGENE CORPORATION;WASHINGTON UNIVERSITY
发明人:
HRUSKA, KEITH,FANG, YIFU,SMITH, WILLIAM,CHEN, NIANHANG
申请号:
CA2964129
公开号:
CA2964129A1
申请日:
2015.10.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Provided herein are methods of treating diseases associated with vascular calcification and/or cardiovascular disease, and/or bone resorption in a subject, by using the level of a biomarker, in particular, snail homolog I (Snail), phosphosmad2, phosphosmad3, urinary protein, dickkopf homolog I (Dkkl), collagen type 1 alphal (Collal), activin (i.e.free activin), runt-related transcription factor 2 (Runx2 ), alkaline phosphatase (Alp), bone-specific alkaline phosphatase (BSAP), C-terninal type 1 collagen telopeptide (CTX), osterix, Klotho, alpha-smooth muscle actin (alpha-SMA), myocardin (JVIYOCD), activin receptor type 2A (ActRIIA), axis inhibition protein 2 (Axin2), and/or smooth muscle protein 22-alpha (Sm22-alpha), as an indicator(s) of responsiveness of the subject to the treatment, efficacy of the treatment, or appropriate dosage tor the treatment with an activin type II receptor signaling inhibitor.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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