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Reprogramming Blood Cells to Pluripotent and Multipotent Stem Cells
专利权人:
Linzhao Cheng
发明人:
Linzhao Cheng
申请号:
US13395916
公开号:
US20120301438A1
申请日:
2010.09.14
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention is based on the seminal discovery that cord blood (CB) and adult bone marrow (BM) CD34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of CB and adult bone marrow (BM) CD34+ cells from subjects without any pre-treatment. Provided are methods for reprogramming blood cells of a subject. Also provided are methods of disease modeling and methods of generating subject-specific differentiated cells. In addition, the invention provides methods of identifying an agent that alters a function of subject-specific differentiated cells as well as isolated pluripotent or multipotent stem cells reprogrammed from blood cells.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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