INGO KONETZKI,CHRISTIAN HESSLINGER,FLORIAN JAKOB,TOBIAS CRAAN,PAUL RATCLIFFE,JASON J. SHIERS
申请号：
MX2015009677
公开号：
MX2015009677A
申请日:
2014.02.03
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme. The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme. Methods and apparatus for determining fluid characteristics are disclosed herein. An example apparatus includes a housing including an electrically insulating pane thermally insulated from the housing. The pane has an exterior surface to be disposed in a fluid and an interior surface to be isolated from the fluid. The example apparatus further includes a sensor including an electrical resistor coupled directly to the interior surface of the pane. The electrical resistor has an electrical resistance corresponding to a temperature of the electrical resistor.La invención se refiere a compuestos de pirimidina condensada sustituida novedosos de la fórmula general (I) en la cual los agrupamientos químicos, sustituyentes e índices son como se definen en la descripción, y a su uso como medicamentos, en particular como medicamentos para el tratamiento de condiciones y enfermedades que se pueden tratar mediante inhibición de la enzima PDE4.
