PROBLEM TO BE SOLVED: To provide a synthetic route for ivabradine in a high yield, which can eliminate the use of a hydride donor such as borohydride or noble metals such as a palladium catalyst, and which is useful in treatment and prevention of various kinds of clinical conditions of myocardial ischemia such as angina, myocardial infarction and rhythm disturbance associated with them, in various clinical conditions including the rhythm disturbance, particularly, supraventricular rhythm disturbance, and further in cardiac failure.SOLUTION: There are provided a process for synthesizing ivabradine represented by formula (I), an addition salt thereof with pharmaceutically acceptable acid, and a hydrate thereof.【課題】収率が高く、ホウ化水素のようなヒドリドドナー、またはパラジウム触媒などの貴金属の使用を省くことを可能にする、狭心症、心筋梗塞及び付随する律動障害のような、心筋虚血の種々の臨床的状況の治療又は予防において、また律動障害、特に上室性律動障害を含む種々の病態において、さらに心不全において有用なイバブラジン合成経路の提供。【解決手段】式（Ｉ）：で示されるイバブラジン、薬学的に許容され得る酸とのその付加塩及びその水和物の合成方法。【選択図】なし
