A patient support system, comprises a patient support having a base and an upper surface, the upper surface moveable relative to the base in a direction along at least one of a first axis, a second axis orthogonal to the first axis, and a third axis orthogonal to the first and second axes; and a control unit for controlling movement of the upper surface, the control unit defining a longitudinal axis. The direction of movement of the upper surface relative to the base is determined by the orientation of the longitudinal axis of the control unit relative to the patient support.