СРЕДСТВО ДЛЯ КОРРЕКЦИИ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЙ КЛЕТОК ОРГАНОВ И ТКАНЕЙ И/ИЛИ ОРГАНОВ И ТКАНЕЙ ЧЕЛОВЕКА, НА ОСНОВЕ ГЕНА GPX3, СВЯЗАННЫХ С ОКСИДАТИВНЫМ СТРЕССОМ, СПОСОБ ПОЛУЧЕНИЯ И ИСПОЛЬЗОВАНИЯ
Savelieva Natalia,Савелиева Наталиа,Gamolski Anton,Гамолски Антон
申请号：
RU2016101626
公开号：
RU0002651758C2
申请日:
2016.01.20
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine and relates to a means for correcting the pathological conditions of cells of organs and tissues and/or human organs and tissues based on the GPX3 gene associated with oxidative stress, where the cells of organs and tissues are selected from cells of fibroblasts, keratocytes and epithelial cells of the eye, chondroblasts organs and tissues are selected from the skin, the mucous membrane of the human mouth or the human muscle tissue, which is a complex of biologically active gene therapy substances, each of a complex of biologically active gene therapeutic substances is a genetic construct based on a vector plasmid comprising the cDNA portion of the GPX3 gene and also containing regulatory elements that transcribe this sequence in eukaryotic cells, namely in cells of human organs and tissues, in combination with or without a transport molecule. Group of inventions also relates to a method for producing said agent for correcting the pathological conditions of cells of organs and tissues and/or human organs and tissues based on the GPX3 gene associated with oxidative stress a method of using said agent for correcting the pathological conditions of cells of organs and tissues and/or human organs and tissues based on the GPX3 gene associated with a quantitative reduction in the GPX3 protein.EFFECT: group of inventions provides a high and stable level of the target protein in the cells.5 cl, 18 ex, 20 dwgГруппа изобретений относится к медицине и касается средства для коррекции патологических состояний клеток органов и тканей и/или органов и тканей человека, на основе гена GPX3, связанных с оксидативным стрессом, где клетки органов и тканей выбраны из клеток фибробластов, кератоцитов и эпителиальных клеток глаза, хондробластов органы и ткани выбраны из кожи, слизистой оболочки рта человека или мышечной ткани человека, представляющего собой совокупность биологически активных генно-терапевтических субстанций,
