Aminoquinazolina Derivatives. Its Salts and Pharmaceutical formulations useful for the Modulation of the activity of Protein Tyrosine Kinase and the Modulation of the Inter - and / or intracellular signalling.Also pharmaceutically acceptable compositions comprising the compounds and Methods of use aminoquinazolina of the compositions in the treatment of disorders hiperproliferativos in Mammals. In particular Human.Claim 1: a compounds of the formula (1) or one of its Geometric isomers, stereoisomers, taut u00f3meros, n-oxides, hydrates, solvates and pharmaceutically acceptable salts or prodrugs metabolites, where: r u1d43 is aryl, heteroaryl or heterociclilo unsaturated alkyl or r u1d47 is； H； r u1d9c is H, alkyl, haloalquilo heteroalquilo, ether, alkyl, cycloalkyl, aryl, heterociclilalquilo,Aralquilo, heteroaryl or heteroarilalquilo； each of x u00b9 and X is independently, S, o, ch u2082 or NH； (ch u2082 is - - - (q) x u2074 u2096 ch u2082) - or - (ch u2082) Q -； each B and e are, independently, a Link, or ch u2082； X is n, C, CH or cr u02e3； the rest of formula (2) is carbociclilo, heterociclilo , aryl or heteroaryl； x u2074 is o, s or NH； each is r u1d48, Independent, - ch = cHC (= o) - nr u00b9r u00b2, r u00b9 (S = o) u1d4d, r u00b9 - S (= o) - u1d4do,- You r u00b9 u1d4d, r u00b9 (= o) - C (= o) -, - C (= o) r u00b9 - r u00b9o ( u2071 ch u2082) - or - (ch u2082) u02b2 -, - (ch u2082) u2071 - nr u00b9r u00b2, oxo alkyl ether, h, F, CL, BR, I, Hydroxy, mercapto, amino, carboxy alkyl, cyano, Nitro, alquilamino, replaced with alkyl, Hydroxy, alkoxy, haloalquilo, heteroalquilo, alquenilo, alquinilo, cicloalqu ILO, heterociclilo, aryl, heteroaryl, aralquilo, heteroarilalquilo, aminosulfonilo, carbamoilo, arilamino,Heteroarilamino, arilalquilamino, heteroarilalquilamino, heterociclilamino, heterociclilalquilamino, ariloxi, heteroariloxi, arilalcoxi, heteroarilalcoxi, heterocicliloxi or heterociclilalcoxi； r u02e3 is CH = cHC (= o) nr u00b9r u00b2, r u00b9 - S (=
