Yissum Research Development Company of the Hebrew University of Jerusalem;The Trustees of Columbia University;Morria Biopharmaceuticals
发明人:
Prince, Alice,Yedgar, Saul,Yuval, Cohen
申请号:
AU2006278657
公开号:
AU2006278657B2
申请日:
2006.08.01
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
This invention provides for the use of compounds represented by the structureof the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing,ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing ora spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptablemonomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; andn is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amideor an esteric bond in treating a subject suffering from cystic fibrosis, reducingor delaying the mortality of a subject suffering from cystic fibrosis or amelioratingsymptoms associated with cystic fibrosis.