In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans. In some embodiments, the compositions of the disclosure may be used to treat or prevent sideroblastic anemias and myelodysplastic syndromes or one or more complications associated sideroblastic anemias and myelodysplastic syndromes.在某些態樣中,本發明提供用於增加脊椎動物(包括齧齒類及靈長類,及特定言之人類)之紅血球及/或血紅素含量之組合物及方法。在一些實施例中,本發明組合物可用於治療或預防含鐵胚血球性貧血及骨髓發育不良症候群或一或多種與含鐵胚血球性貧血及骨髓發育不良症候群相關聯之併發症。
