The present invention concerns a process for the preparation of a material comprising collagen the fibers of which are coated with nanoparticles, comprising the steps consisting in:1) providing an aqueous dispersion comprising collagen and nanoparticles comprising an amphiphilic lipid, a solubilising lipid, and a co-surfactant,2) drying the aqueous dispersion of step 1) to obtain the material comprising collagen the fibers of which are coated with nanoparticles,the material obtainable by this process and its uses for wound healing dressings, 3D cell culture materials, tissue engineering, as a sensor, in diagnostic, pharmaceutical, or cosmetic industry.