The present invention relates to immune restricted peptides, and especially HLA-A2 restricted peptides. Specifically, the present invention relates to immune restricted peptide according to the general formula (I): wherein: - P1 is selected from the group consisting of am-phg, PHG, 3-PYRA, 3-THI, SOME, CSCF3 and CSME - P2 is a naturally, or non-naturally, occurring amino acid comprising a hydrophobic linear or branched or fluorinated substitution - P3 is a naturally, or non-naturally, occurring amino acid comprising a hydrophobic linear or branched substitution - P4 is a naturally, or non-naturally, occurring amino acid comprising a methylated alpha nitrogen atom - Pm is a naturally occurring amino acid, n is an integer of 1 to 9, preferably 1 to 4, more preferably 2 or 3 - PC-2 is a naturally, or non-naturally, occurring amino acid comprising a fluorinated aromatic substitution - PC-1 is a naturally, or non-naturally, occurring amino acid - PC is a naturally, or non-naturally, occurring amino acid comprising unsaturated or saturated side chains and/or carboxyl isosteresor a saturated linear carbon chain containing 2 to 4 carbon atoms with or without an oxygen atom or a sulphur atom within the chain and/or a carboxyl isostere.Cette invention concerne des peptides restreints au système immunitaire, et en particulier, des peptides HLA-A2 restreints. Plus spécifiquement, cette invention concerne des peptides restreints au système immunitaire de formule générale (I): Dans la formule générale (I), - P1 est choisi dans le groupe constitué par am-phg, PHG, 3-PYRA, 3-THI, SOME, CSCF3 et CSME - P2 est un acide aminé naturel ou non portant une substitution hydrophobe linéaire ou ramifiée ou fluorée - P3 est un acide aminé naturel ou non portant une substitution hydrophobe linéaire ou ramifiée - P4 est un acide aminé naturel ou non comprenant un atome dazote en alpha méthylé - Pm est un acide aminé naturel, n est un nombre entier de 1 à 9, de préférence, de 1 à 4, de préfé
