As for topic of this invention, being the dissolvedly the medicinal effect component which is contained in the dermal absorption sticking medicine for the adhesion base scanty basic medicine, dermal absorptivity and medicinal effect persistence is enough satisfactory, at the same time, being the sticking medicine which is superior in time-dependant stability of the medicine in the formulation, there are times when it offers the dermal absorption sticking medicine which can achieve the improvement of compliance and the simplification of taking method. As for the aforementioned topic, logarithm value of the octanol/water distribution coefficient in separation type has the basic medicine and the adhesion base and the carboxyl group of 3 or more, it is solved (by the dermal absorption sticking medicine which contains with meta) acrylic acid copolymer.本発明の課題は、経皮吸収貼付剤中に含有される薬効成分が粘着基剤に対する溶解性に乏しい塩基性薬物であっても、経皮吸収性および薬効持続性が極めて良好であり、かつ、製剤中における薬物の経時的安定性に優れた貼付剤であって、コンプライアンスの向上および服用方法の簡便化を達成しうる経皮吸収貼付剤を提供することにある。前記課題は、遊離型におけるオクタノール/水分配係数の対数値が3以上の塩基性薬物と、粘着基剤およびカルボキシル基を有する(メタ)アクリル酸コポリマーとを含有する経皮吸収貼付剤により解決される。
