The invention concerns new pharmaceutical formulations containing a blend ofpalmitoyl ethanolamide or PEAand stearoyl ethanolamide or SEA compounds as active principles. Theformulation is suitable for oral, parenteral, topical, transdermic,rectal, sublingual, nasal, topical, transdermic, rectal, nasal or sublingualadministration, whereby the dosage form of saidformulations can be in patches, suppositories, ovules, pessaries, aerosol orspray, emulsions, suspensions, solutions. Said pharmaceuticalformulations are useful for the treatment or prevention of skin pathologies,for the treatment or prevention of gynaecologicalpathologies, for the treatment of disorders or pathologies characterised byimproper metabolism of fatty acids as well as for thetreatment of disorders or pathologies characterised by inflammatory states.