Auerbach, Wijtek,Dechiara, Thomas,Poueymirou, William,Frendeway, David,Valenzuela, David
申请号：
AU2011265306
公开号：
AU2011265306A1
申请日:
2011.06.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile XY female animals. Methods and compositions are described for making fertile female animals in an FO generation from a donor XY cell and a host embryo, as are methods for making F1 progeny that are homozygous for a modification from a heterozygous FO fertile male and a heterozygous FO fertile female sibling.
