The present invention provides compounds of the Formula I: wherein X is a bond or CH2 R is selected from the group consisting of R1 and R2 are each independently selected from the group consisting of CH and N R3 is H or CH3 R4 is H or CH3 L is selected from the group consisting of -O(CH2)3-, -C(O)NH(CH2)2-, -CH2C(O)NH(CH2)2-, -(CH2)3N(C(O)CH3)CH2-, -(CH2)2N(C(O)CH3)CH2-, -(CH2)3NH-, (CH2)2OCH2-, -(CH2)4-, -(CH2)2NHCH2-, -(CH2)3O-, and -CH2O(CH2)2- or a pharmaceutically acceptable salt thereof.Compounds of this invention are autotaxin inhibitors.本發明提供式I化合物:其中X為一鍵或CH2;R係選自由以下組成之群:R1及R2各自獨立地選自由CH及N組成之群;R3為H或CH3;R4為H或CH3;L係選自由以下組成之群:-O(CH2)3-、-C(O)NH(CH2)2-、-CH2C(O)NH(CH2)2-、-(CH2)3N(C(O)CH3)CH2-、-(CH2)2N(C(O)CH3)CH2-、-(CH2)3NH-、(CH2)2OCH2-、-(CH2)4-、-(CH2)2NHCH2-、-(CH2)3O-及-CH2O(CH2)2-;或其醫藥學上可接受之鹽。本發明化合物為自分泌運動因子抑制劑。