Immunogenic bacterial vesicles with outer membrane proteins

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专利权人:

Novartis Vaccines and Diagnostics SRL

发明人:

Adu-Bobie, Jeannette,Pizza, Mariagrazia,Norais, Nathalie,Ferrari, Germano,Grandi, Guido

申请号：

AU2012211495

公开号：

AU2012211495A1

申请日:

2012.08.02

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2012211495A120120830.pdf#####ABSTRACT The present invention provides a pathogenic bacterium with a knockout mutation of the meningococcal homolog mitA gene. Knockout of the mItA gene results in spontaneous release of vesicles that can elicit antibody responses which are comparably higher than that of the wild-type. Further provided are compositions comprising of meningococcal vesicles which are particularly useful in vaccine preparation.

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