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Compounds for use in the treatment of autoimmune diseases, immunoallergic diseases and rejection of organ or tissue transplants
专利权人:
NOVAREMED LTD.
发明人:
KAPLAN, ELIAHU
申请号:
ES03758581
公开号:
ES2535975T3
申请日:
2003.10.01
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound represented by the structure of formula I: ** Formula ** in which: the broken line represents a single or double bond; R1 and R2 are the same or different and, independently of each other, are groups represented by the formulas: ** Formula ** or in which R5 is H, OH or OR6, in which R6 is a linear or branched C1-C4 alkyl ; AB is a group represented by the formula: ** Formula ** o and (a) m is an integer of 0 or 1, n is an integer of 1-500, and X is O, -CH2O, -CH2CH2O, - CH (CH3) CH2O or -CH2CH (CH3) O; or (b) m is 1, n is an integer from 0-500, and X is -CH2O, -CH2CH2O, -CH (CH3) CH2O or -CH2CH (CH3) O; and Z is -CH2CH2O, -CH (CH3) CH2O or -CH2CH (CH3) O; or of formula II: ** Formula ** in which R is a polyalkylene glycol polymer having n units, in which n 5 is an integer from 1-100, and R7 and R8 are groups represented by the following formulas in the combinations shown: ** Table ** and salts or hydrates thereof; provided that said compound is not N-cinnamoyl-D, L-phenylalaninol, N- [1-hydroxymethyl-2- (1H-5 indol-3-yl) -ethyl] -3-phenyl-propionamide, N- [1- hydroxymethyl-2-phenyl-ethyl] -3- (4-hydroxy-phenyl) -propionamide, N- (1-hydroxymethyl-2-phenylethyl) -3- (1H-indole-3-yl) -propionamide, N- ( 1-hydroxymethyl-2-phenyl-ethyl) -3-phenyl-propionamide, N- [1-hydroxymethyl-2- (4- hydroxyphenyl) -ethyl] -3-phenyl-propionamide or N- [1-hydroxymethyl-2- (1H-imidazol-4-yl) -ethyl] -3- (4-hydroxyphenyl) -propionamide.Compuesto representado por la estructura de fórmula I:**Fórmula** en la que: la línea discontinua representa un enlace sencillo o uno doble; R1 y R2 son iguales o diferentes e, independientemente entre sí, son grupos representados por las fórmulas:**Fórmula** o en las que R5 es H, OH u OR6, en el que R6 es un alquilo C1-C4 lineal o ramificado; A-B es un grupo representado por la fórmula:**Fórmula** o y (a) m es un número entero de 0 ó 1, n es un número entero de 1-500, y X es O, -CH2O, -CH2CH2O, -CH(CH3)CH2O o -CH2CH(CH3)O; o (b) m es 1, n es un n
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