Christine Esau,Eric E. Swayze,Balkrishen Bhat,Garth A. Kinberger
申请号：
US12161286
公开号：
US08129515B2
申请日:
2007.01.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA activity in a cell.
