The invention discloses short-acting factor Ⅴ II peptides.The half-life period of shortening is that the treatment of acute bleeding and similar obstacles is desired.The sialylated and/or glycosylated modification of factor Ⅴ II and its variant generates the peptide available for treatment acute bleeding illness.The polynucleotides of peoples coagulation factors VII variants and the such variant of coding are provided herein, comprising and the such variant of expression carrier and host cell, the method for obtaining such variant uses the method for such variant, the composition of the variant, and other associated inventive features.
