The present invention relates to a kind of manufacture method for being used to manufacture prefilled splicing detachable needle syringe, it comprises the following steps:Syringe body (2) will be arranged on for the needle guard mechanisms (D) for protecting syringe needle, the needle guard mechanisms include:Can along longitudinal axis its cover syringe needle front extended position and its do not cover movable outer sleeve between the retracted position of syringe needle, reset components and needle guard for making the sleeve reset to front extended position;The syringe body (2) that will be equipped with needle guard mechanisms is arranged in the groove seat (O204) being arranged in support member (200);Support member (200) is placed in container (100) with shipping container;Support member is removed from container;Each syringe body is loaded with active component;Insert the piston into each syringe;And remove syringe (1) for detecting and labelling from its support member.