Method for the decontamination and disinfection of a transport vehicle, and control device for said decontamination. The method according to the invention comprises at least one heat treatment phase of the vehicle cabin, or of at least one cabin compartment, intended for transporting, by injecting a hot gas into the same at a temperature that guarantees the elimination of the pathogens, said temperature being comprised between 0° C. and 91° C. The control device for the decontamination comprises: a control unit (1); a user interface (2); a series of conveniently distributed temperature sensors (3); and a memory (5) for the storage of data relating to dates, temperatures and other variables relating to the decontaminations carried out, as well as the identification of the vehicle on which the decontamination process is carried out.