JAKABCINOVA, ANDREA;ULICNA, CSILLA;UNIVERZITA PAVLA JOZEFA €AFARIKA V KO€ICIACH;UNIVERZITA PAVLA JOZEFA €；AFARIKA V KO€；ICIACH
发明人:
JAKABCINOVA, ANDREA,ULICNA, CSILLA,PUCATOVA, MARTA,JAKABCIN, PATRIK,ULICNY, JOZEF
申请号：
CA3037826
公开号：
CA3037826A1
申请日:
2017.10.05
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A contrast mixture with increased affinity and selectivity to neoplasms of the gastrointestinal tract, being of three components and consisting of 0.0005 - 0.01 % by weight of low-molecular component, 0.05 - 6 % by weight of high-molecular component and isotonic solution, wherein low-molecular component is a contrast substance, which is a colouring agent used in food industry and pharmacy and high-molecular component is a colloid modulator of velocity designed to decelerate diffusion of the contrast mixture into a tissue in such manner that the velocity of diffusion into healthy tissue of gastrointestinal tract and the velocity of diffusion into neoplasm tissue of gastrointestinal tract is different. In an embodiment, the colouring agent is the sodium and/or clacium salt of [4-(alpha-(4-diethylaminophenyl)-5-hydroxy-2,4-disulphophenylmethylidene)-2,5-cyclohexadiene-1-ylidene] diethylammonium hydroxide or 3,7-bis(Dimethylamino)-phenothiazin-5-ium chloride and the colloid modulator of velocity is a starch, pectin, agar-agar (agarose and agaropectins) and/or non-linearly branched amylopectins. A use of the contrast mixture for colour sharp distinction of the interface between healthy tissue and neoplasm tissue of gastrointestinal tract.
