Harald Rau,Felix Cleemann,Ulrich Hersel,Silvia Kaden-Vagt,Torben Lessman,Thomas Wegge
申请号：
US13387940
公开号：
US09138462B2
申请日:
2010.07.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising an insulin linker conjugate D-L1, wherein D is insulin； and -L1 is:wherein the dashed line indicates the attachment to one of the amino groups of the insulin by forming an amide bond. The invention further relates to pharmaceutical compositions comprising said prodrugs as well as their use as a medicament for treating or preventing diseases or disorders which can be treated by insulin.
