Binding Protein capable of binding to Dll4； which includes the Construction of Antibody conjugated Antibody； Protein； Nucleic AcidVector and host Cell comprising the Antibody composition for releasing a； Binding Protein； method to reduce the activity of the Human Dll4.
LI, YINGCHUN,HSIEH, CHUNG-MING,GU, JIJIE, JAMES,CHEN, MINGJIU,MORGAN-LAPPE, SUSAN
申请号：
CL2012002416
公开号：
CL2012002416A1
申请日:
2012.08.31
申请国别(地区):
CL
年份:
2013
代理人:
摘要：
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.<；p>；PROTEÍ；NAS DE UNIÓ；N A DLL4, QUE INCLUYEN ANTICUERPOS, ANTICUERPOS CON INJERTO DE CDR, ANTICUERPOS HUMANIZADOS Y FRAGMENTOS DE UNIÓ；N A DL1-4 DE LOS MISMOS, PROTEÍ；NAS QUE SE UNEN A DL1-4 CON GRAN AFINIDAD Y PROTEÍ；NAS DE UNIÓ；N A DLL4 QUE NEUTRALIZAN LA ACTIVIDAD DE DL1-4 Y/O VEGF. LAS PROTEÍ；NAS DE UNIÓ；N A D1-1-4 SON DE UTILIDAD PARA TRATAR O PREVENIR DISTINTOS TIPOS DE CÁ；NCER Y TUMORES Y EN ESPECIAL PARA TRATAR O PREVENIR LA ANGLOGÉ；NESIS DE TUMORES.<；/p>；<；p>； ； ；<；/p>；<；p>； ；<；/p>；<；p>； ；<；/p>；
