#$%^&*AU2019272064A120191219.pdf#####C: Interwo n NRPortbl DCC DAR 19603278_I.docx-29/ll/2019 ABSTRACT A tablet including high dosage of 8-fluoro-2-(4-[(methylamino)methyl]phenyl)1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one camsylate salt has been disclosed. The invention is directed to high dosage strength tablets of rucaparib. In some embodiments, the tablet includes 45-90% w/w njcaparib camsylate. In some embodiments, the dry granulated tablet includes 45-90% w/w rucaparib camsylate. One such embodiment is a tablet containing at least 200 mg rucaparib. Another embodiment is a tablet containing at least 300 mg rucaparib.WO 2016/028689 PCT/US2015/045522 1/15 Figure 1 5.0 -r---- --- ------- S4.5 --. Formulation 1 M. 4.0 --- Formulation 2 3.5 -- +--Formulation 3 3.0 - - Formulation 4 b 2.5 ---... Formulation 5 CD 2.0 - - -* 1.5 S1.0 H- 0.5 0.0 0 50 100 150 200 250 Compression Stress (MPa)
