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GRANULES FOR PHARMACEUTICAL PREPARATIONS, METHODS AND APPARATUS FOR THEIR PRODUCTION
专利权人:
Ferring B.V.
发明人:
Carsten Hoeg-Moller,Crilles Casper Larsen,Jorgen Wittendorff,Birgitte Nissen,Kenneth Manby Pedersen,Tue Hansen,Helle Poulsen
申请号:
US14279806
公开号:
US20140328934A1
申请日:
2014.05.16
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Disclosed are improved granular pharmaceutical preparations, together with improved methods and apparatus for preparation of granules for use in such preparations. Such methods are especially useful for making granules for solid oral dose pharmaceutical preparations, and are particularly suited to the production of granules comprising 5-aminosalicylic acid (5-ASA) for the treatment of inflammatory bowel disease. The granules exhibit a more sharply peaked length distribution, and hence aspect ratio distribution, and have a consequently much sharper dissolution profile after further processing.
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