GANGLOFF, ANTHONY R,JENNINGS, ANDREW JOHN,JONES, BENJAMIN,KIRYANOV, ANDRE A
申请号：
NZ59432210
公开号：
NZ594322A
申请日:
2010.01.21
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
594322 Disclosed is an inhibitor of Poly (ADP-ribose) Polymerase (PARP), having the structure of Formula I, wherein the substituents are as described within the specification. An example of a compound of Formula I is (S)-3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-6a,7,8,9-tetrahydropyridol[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one. Further disclosed are pharmaceutical compositions comprising a compound of Formula 1, and the use of a compound of Formula I in the manufacture of a medicament for the treatment of a disease or condition for which PARP activity contributes to the pathology and/or symptomology, such as cancer, cardiovascular diseases, inflammatory diseases and neurodegenerative diseases.
