The present invention pertains to a vaccine comprising in combination non-live antigens of Lawsonia intracellularis , of Mycoplasma hyopneumniae and Porcine circo virus, and a pharmaceutically acceptable carrier. The invention also pertains to a kit comprising a first container having contained therein non-live antigens of Lawsonia intracellularis , one or more other containers having contained therein Mycoplasma hyopneumoniae and Porcine circo virus antigens and instructions for mixing the antigens of Lawsonia intracellularis , Mycoplasma hyopneumoniae , and Porcine circo virus to formulate one combination vaccine suitable for systemic vaccination.
